济南白癜风医院 http://pf.39.net/bdfyy/bdfyc/190326/6997150.html异位性皮肤炎（atopicdermatitis）这一病名是由瓦也斯（Wise）和苏兹伯格（Sulzberger）在年最早提出的。异位性皮肤炎，又名异位性湿疹或遗传过敏性湿疹，是一种与遗传有密切关系的皮肤疾病，因遗传导致皮肤异常而发生病变，会反复发作且搔痒难当即异常敏感，好发于婴幼儿时期，也因此，有些人会称之为“婴儿湿疹”。异位性皮肤炎属于慢性、复发性、瘙痒性皮肤病。异位性的含义：（1）有易患哮喘，过敏性鼻炎，湿疹的家族性倾向；（2）对异种蛋白过敏；（3）血清中IGE值高；（4）血液嗜酸粒细胞增多。典型的异位性皮肤炎除有特定的湿疹临床表现外，还具有上述四个特点。科学家们对异位性皮肤炎的认识尚不一致。病因比较复杂，一般认为与多种因子如遗传、环境等有关。在一项新的临床研究中，来自韩国首尔大学和釜山大学的研究人员指出利用来自脐带血的干细胞进行治疗可能是一种有效的方法来治疗中重度湿疹或者说异位性皮肤炎。相关研究结果于年6月3日在线发表在StemCells期刊上，论文标题为“ClinicalTrialofHumanUmbilicalCordBlood-derivedStemCellsfortheTreatmentofModerate-to-SevereAtopicDermatitis:PhaseI/IIaStudies”。在这项临床试验中，34名病人被随机地分配接受低剂量或高剂量脐带血干细胞皮下注射。在第12周，55%接受高剂量注射的病人的湿疹面积与严重度指数（eczemaareaandseverityindex,EASI）下降50%。异位性皮肤炎的免疫相关标志物水平也显著下降。“这项研究是首项研究证实患有中重度异位性皮肤炎的病人对源自脐带血的干细胞治疗作出反应”，论文通信作者Tae-YoonKim博士说，“对病人进行单一的干细胞治疗导致在整个12周的随访期内疾病症状显著和持久地改善。”
ClinicalTrialofHumanUmbilicalCordBlood-derivedStemCellsfortheTreatmentofModerate-to-SevereAtopicDermatitis:PhaseI/IIaStudies
doi:10./stem.
Hyung-SikKim1,?,?,§,JiHyunLee4,§,Kyoung-HwanRoh5,HeeJinJun4,Kyung-SunKang1,5,?,*andTae-YoonKim
Mesenchymalstemcells(MSCs)havebeenproventobetherapeuticallyeffectiveagainstatopicdermatitis(AD)inpreclinicalstudies.However,thesafetyandefficacyofMSCsagainstADhavenotyetbeeninvestigatedinaclinicalstudy.Toestablishthesafetyandefficacyofhumanumbilicalcordblood-derivedMSCs(hUCB-MSCs)inAD,thirty-fouradultpatientswithmoderate-to-severeADwereenrolledintwophasetrialswithafollow-upfor1monthand3months,respectively.Patientswererandomlyallocatedtoreceivelowdose(2.5x)orhighdose(5.0x)ofhUCB-MSCssubcutaneously.AnEczemaAreaandSeverityIndex(EASI)score,investigatorsglobalassessment(IGA)score,SeverityScoringforAtopicDermatitis(SCORAD)score,adverseeffectassessmentsandserumbiomarkerlevelswereevaluatedasendpoints.AsingletreatmentofhUCB-MSCsresultedindose-dependentimprovementsinADmanifestation.Fifty-fivepercentofpatientsinhighdosehUCB-MSC-treatedgroupshoweda50%reductionintheEASIscore.TheIGAscoreandSCORADscoredecreasedby33%and50%,respectively,inhighdose-treatedgroup.Particularly,theadministrationofhighdosehUCB-MSCsreducedthepruritusscoreby58%.TheserumIgElevelsandnumberofbloodeosinophilsweredown-regulatedbythetreatment.Noseriousadverseeventsoccurredandnoneofthepatientsdiscontinuedthetrialduetoadverseevents.ThisisthefirstreporttodemonstrateamarkedimprovementofADfeatureswithcelltherapeutics.ThesedatasuggestthattheinfusionofhUCB-MSCsmightbeaneffectivetherapyforpatientswithmoderate-to-severeAD.Thisarticleisprotectedbycopyright.Allrightsreserved.
来源：生物谷
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